Friday, July 22, 2022

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FORENSIC MEDICINE:Sudden, Unexpected, Natural Death in Adults

 Topic: Sudden, Unexpected, Natural Death in Adults

 

Subtopics:

Introduction

Death from cardiac causes

Death from non-cardiac causes

 

The reviews of the extensive literature on sudden death agree that there is a great inconsistency in definitions of sudden death. The question is “how sudden is sudden?”. The WHO definition of a sudden death is that it is someone who dies within 24 hours of appearance of symptoms. However, in forensic sense, most of deaths are in minutes or even in seconds of appearance of symptoms. A sudden death is not necessarily unexpected death and an unexpected death is not necessarily sudden, but very often the two are in combination. The vast majority of sudden death are due to natural causes. Most cases of sudden unexpected natural death result from a variety of chronic conditions that may seem to offer no immediate threat to the individual. Most sudden, unexpected deaths occur between the ages of one month and thirty years and after seventy years. The most common causes of death are clinically silent degenerative diseases.

 

Causes: Sudden, unexpected natural deaths can be divided into two essential categories: a) Deaths from cardiac causes b) Deaths of non-cardiac etiology.

 a) Death from cardiac causes: Death from cardiac causes occur in two situations

a) There is a significant anatomic alteration in the heart such that the functional abnormalities are obvious.

b) There is no anatomical abnormalities found during autopsy.

When death is due to later situation then it is called functional death i.e. no anatomical abnormalities in found in the heart.

 

Where a natural death is very rapid, perhaps virtually instantaneous, the cause is invariably cardiovascular. Cardiovascular system accounts for the vast majority of sudden deaths. Cardiovascular disease is by far the most common cause of death in the Western world of which more than 80% are due to coronary atherosclerosis. Hypertension accounts for a much smaller number of deaths but may be under-reported since many pathologists are not willing to designate hypertensive cardiovascular disease as a cause of death in the absence of supporting clinical data. 

 

a) Causes of functional death

Spontaneous Ventricular Fibrillation: A meanwhile healthy man can die from ventricular fibrillation as he may collapses suddenly or during exertion. In those patients evidence indicates that these individuals have electrically unstable hearts and that they suffer a fatal dysrhythmia related to adrenergic discharge. The manner of death may be natural, accidental, or homicidal.

Vagal cardiac inhibition: This may be the cause of death within seconds to minutes followed by trauma. The death is classified as accidental as no obvious wound is produced. Examples of such trauma are blow to larynx, kick to scrotum, blow to upper abdomen, etc. The death in these scenario can be due to homicide as well.

Electrocardiographic Syndromes: Certain syndromes or functional abnormalities that are only depicted by echocardiography may be the cause of sudden cardiac death in adults. Examples are   Wolf Parkinson White Syndrome (WPW) syndrome, long QT syndrome, sinus sick syndrome ,etc.

b) Cause of death to structural abnormalities in the heart:

Atherosclerosis of coronary arteries: The sign or symptom in patient with coronary artery disease may be sudden death that may occur during exertion, taking bath, sexual intercourse , sleeping or any other time.  The cause of death in such patient is myocardial ischemia or infarction as atheromatous plaque occlude blood to heart itself. The plaques occludes the coronary arteries supplying the heart muscles . Sudden death is triggered by certain environmental factors. Exercise increases heart rate and causes greater oxygen demand by the myocardium. Exercise also increases catecholamine levels that sensitize the myocardium to dysrhythmias. Severe changes of heat and cold in the climate may also stress the heart and predispose to anginal attacks and sudden death due to myocardial infarction. Most individuals who die suddenly and unexpectedly from coronary occlusion have at least two vessels involved.  Atheroslerotic occlusion of at least 75 percent of the coronary arteries is required for infarction to  occur. Most commonly involved coronary artery is left anterior descending artery followed by right coronary artery. Coronary atherosclerosis is a very common finding at autopsy, and it develops over a period of years and is compatible with a vigorous life. One must take into account all of the findings and circumstances of the case before a final conclusion is justified. Even when a recent myocardial infarct is present, the victim may have died from some other cause entirely.

Time determination of death by analyzing the histology of  infarct tissue of the heart:

<5 hours: PAS stained myocytes

5-24 hours: Appearance of neutrophils to appearance of degenerating neutrophils

1-3 days: Exclusively neutrophils and their degenerating forms

4-6 days: Neutrophils, eosinophils, macrophages, pigment, fibroblasts, capillaries

7-14 days: Neutrophils, eosinophils, macrophages, pigment, fibroblasts, capillaries, lymphocytes, plasma cells

2-8 weeks: As previous, but no neutrophils

>2 months: Connective tissue condensed; minute foci of necrosis may still persist. Exudate has essentially disappeared, but a small number of lymphocytes and pigmented macrophages may be seen until one year.

Non-atherosclerotic Coronary Artery Disease: Congenital anomalies of the distribution of the coronary arteries can be the etiology of sudden death in adults and children. The anomalies vary:

ü Origin of the left coronary artery from the right sinus of Valsalva with the artery passing between the aorta and pulmonary artery

ü Only a single coronary ostium in the right sinus of Valsalva with the left coronary artery arising from the proximal right coronary artery

ü Origin of the right coronary artery from the left sinus of Valsalva

ü Origin of the left coronary artery from the right sinus of Valsalva with the artery passing dorsal to the aorta rather than between the aorta and pulmonary artery

ü Coronary artery hypoplasia, although no diagnostic criteria have been set forth for this entity.

Sudden death appears to be more likely when the anomalous artery forms an acute angle with the sinus of Valsalva or a right angle in the artery.

Sudden death can also be associated with a condition called "bridging". In this abnormality the left anterior descending, dips down into the myocardium to pursue an intramyocardial course instead of following its usual course in the epicardial fat. Sudden death as a result of this anomaly is also a diagnosis of exclusion and depends upon the totality of autopsy findings and circumstances of death.

Left Ventricular Hypertrophy and Hypertensive cause: Left ventricular hypertrophy is associated with electrical instability like ventricular ectopy and ventricular tachydysrhythmias and thereby, sudden death. The association exists whether coronary atherosclerosis is present or not. Hypertension is the most common etiology of concentric left ventricular hypertrophy, also known as pressure hypertrophy, which involves the septum and free wall symmetrically with no enlargement of the chamber. It may develop in a matter of weeks in hypertension. It may also be associated with aortic valvular disease, thyrotoxicosis, and aortic coarctation. In hypertension the right ventricle is usually also hypertrophied, and the pulmonary pressures are increased. Sometime the only autopsy finding after sudden death is left ventricular hypertrophy. But in hypertensive patients atherosclerosis can be seen.

Myocarditis: It  may occur as the result of  systemic infection, or it mav follow respiratory infection or be of unknown or uncertain origin. It may be acute, subacute, or chronic. It can be caused variety of known etiologic agents, including bacteria, viruses,rickettsia, fungi, protozoa, or helminths. It may also be a manifestation of autoimmune disease. The patient can suddenly die from arrhythmias caused by myocardium necrosis. Dysarrthymias like premature ventricular contractions and ventricular tachycardia are the cause of sudden death .

Cardiac Valvular Disease : Rheumatic fever is the major cause of valvular disease like  mitral and aortic stenosis in the developing countries like Nepal . So those findings are quite commonly found in autopsies on cases of sudden death in Nepal. Calcific aortic stenosis may result from congenital malformations of the valve usually a bicuspid valve , rheumatic inflammation in which the cusps become fused, secondary calcification of the bicuspid valve leaflets. plications. The most common valvular disorders currently associated with sudden death  are mitral valve prolapse syndrome (also referred to as myxomatous degeneration of the mitral valve, floppy mitral valve,  Barlow's syndrome) and aortic stenosis. In intravenous drug abusers sudden death can occur from an acute valvulitis, usually of the tricuspid valve.

 

 

Other causes of sudden unexpected death from cardiac causes are as follows:

Congenital heart diseases

Valvular heart diseases (rheumatic, syphilitic, etc.)

Hypertensive diseases

Infections (myocarditis, post infectious myocardial degeneration)

Cardiac tamponade :  After ruptured myocardial infarct, trauma, there is collection of blood in pericardial sac. About 250 to 300 ml blood may act fatal, making heart unable to function normally, resulting in cardiac standstill leading to death.

 Obscure conditions such as cardiomyopathies, Fiedler’s myocarditis, etc.

 Aortic aneurysms of atherosclerotic or dissecting type

Death from non-cardiac causes:

Respiratory System : Most of the causes of sudden death within the respiratory organs are again vascular. Pulmonary embolism is a common and in fact is the most under-diagnosed cause of death. In almost every case, the source of emboli is in the leg veins, as pelvic thrombosis is very rare. After any tissue trauma, especially where immobility or bed rest occurs, deep vein thrombosis develops. Some produce no lung lesions at all, others produce infarcts, which may or may not lead to clinical signs, and a minority block major vessel and cause death. Majority of cases of pulmonary embolism deaths have predisposing cause such as fractures, tissue trauma, surgical operation, burns trauma, bed rest, forced immobility, etc. but others occur unexpectedly in normal people. Various causes of sudden natural death of respiratory system origin are:

Pulmonary embolisms     Massive hemoptysis (from pulmonary tuberculosis) Severe infections such as fulminating viral pneumonia (usually influenza)  Chronic asthma/status asthmatics       Anaphylaxis   Obstruction of respiratory tract

 

Intracranial Vascular Lesions: Commonly encountered intravascular lesions resulting in sudden natural death are:

Intracranial bleeding due to cerebral atheroma and stroke or hypertension

Subarachnoid hemorrhage from ruptured aneurysm

Cerebral thrombosis

Embolisms

Meningitis

Brain tumors, which can result in death due to increased intracranial pressure, sudden hemorrhage from tumor mass, etc.

Idiopathic epilepsy

Functional inhibition of the vagus nerve.

Gastrointestinal System :The major cause of sudden death within the gastrointestinal system are also mostly of vascular origin and they are:

Severe gastrointestinal bleeding due to gastric or duodenal ulcers

Ulcerative colitis, malignancies, etc.

Mesenteric thrombosis and embolism leading to infarction of the gut are not sudden, but may be rapid and remain undiagnosed

 Perforation of peptic ulcer can be fatal in hours if not treated

 Intestinal gangrene due to strangulated hernias and torsion due to peritoneal adhesions can be a fulminant and fatal condition

Aortic aneurysmal rupture

 Diseased viscera undergoing rupture

Fulminant hepatic failure

Acute haemorrhagic pancreatitis.

Gynaecological Conditions : If a women in her child bearing age is found to be dead unexpectedly and suddenly, following should be considered as cause of death:

Complication of pregnancy must be first thought of, just to make a primary exclusion. Haemorrhage in female genital organs could be due to abortion or ruptured ectopic pregnancy, etc. and is an emergency that can result in death from intraperitonial bleeding, unless rapidly treated by surgical intervention.

Endocrinal Causes:Sudden natural deaths occur due to any one of the following: Adrenal insufficiency  Diabetic coma  Myxoedemic crisis  Parathyroid crisis

Iatrogenic Causes: Following may be suspected and may have to be ruled out: Abuse of drugs Sudden withdrawal of steroids    Anesthesia                    Mismatched blood transfusion

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FORENSIC MEDICINE:Examination of sexual assault / rape victim in the living

Topic:  Examination of sexual assault / rape victim in the living.

Sub-topics:

1) Definition

2) Medicolegal Examination

3) Forensic Evidence /Sample collection

4) Documentation 

1) Definition: Legal definition of rape

A man is said to commit “rape” if he has sexual intercourse with a woman under circumstances falling under any of the six following descriptions:

• First– Against her will.

• Second – Without her consent.

• Third – With her consent, when her consent has been obtained by putting her or any person in whom she is interested in fear of death or of hurt.

• Fourth – With her consent, when the man knows that he is not her husband, and that her consent is given because she believes that he is another man to whom she is or believes herself to be lawfully married.

• Fifth – With her consent, when, at the time of giving such consent, by reason of unsoundness of mind or intoxication or the administration by him personally or through another of any stupefying or unwholesome substance, she is unable to understand the nature and consequences of that to which she gives consent.

• Sixth – With or without her consent, when she is under sixteen years of age.

Explanation: Penetration is Surface sufficient to constitute the sexual intercourse necessary to the offence of rape.

Exception: Sexual intercourse by a man with his own wife, the wife not being under fifteen years of age, is not rape.

Dangers of Rape:

The victim may develop shock due to fear which may turn fatal and when the victim survives, may make her mentally deranged temporarily or permanently. She may suffer from haemorrhage due to genital injuries, may be fatal when severe. She may suffer from accidental death like suffocation ,the rapist may cover his hand over her mouth and nostrils preventing the victim from shouting or screaming for help. There maybe the case of  homicidal death for example from strangulation in order to conceal the event, the rapist may kill his victim after rape. The victim may even end her life.

 

Provisions and the laws regarding rape case in Nepal

No. 1 : Having sexual intercourse with an unmarried girl, a widow or someone's wife under sixteen years of age with or without her consent and with one above sixteen years of age without her consent by using force or showing threat or even under inappropriate influence is proved to be a rape case.

No. 2 : For raping a woman within family relationship, the one who rapes will get punishment mentioned in the chapter regarding sexual intercourse within kinship in addition to the punishment in accord with this chapter. As for the case of life imprisonment, the punishment for rape will not be added.

No. 3 : One who commits rape should be imprisoned for six upto ten years if the woman raped is under fourteen years of age, and for three upto five years if the woman is fourteen or above fourteen years of age.

No. 4 : One who knowingly accompanies the one who intends to commit rape, and who grabs the woman or helps in the act should be punished upto one year each. As for the case of a girl under fourteen years of age, he will be punished doubly.

No. 5 : The one who has made an attempt to rape but has not committed rape will get punished equal to half of the one's who has committed it.

No. 6 : If someone has instigated someone else to commit rape, the one who has instigated to perform the act will, in the case of rape having committed, get punishment equal to half of the rapist's, and in the case of attempted but not actually committed rape, he will get equal to half of the attempt maker's punishment.

No. 7: If someone has a sexual intercourse with a prostitution without her consent, the one who commits it will either be fined an amount of Rs. five hundred or imprisoned upto one year.

 

2) Medicolegal Examination of rape victim

Examination of the scene: The forensic pathologist should himself visit the crime scene.

General examination: a) Examination of the clothing

Examination of clothing: The victim should ideally undress herself whenever possible or otherwise assisted by the third party. The person is made to stand over

a wide white paper/cloth to collect any trace evidence that may dislodge while undressing. Followings finding can found out from the clothing.

 

Ø There may be tears in the clothing and loss of buttons can be noticed.

Ø Various stains can be noticed. Those stains may be of blood,semen, saliva, urine, faecal matter, mud ,etc

Ø Other traces evidences like hairs, fibers, grass ,etc can be found.

Ø Stains and any other trace evidences  should be collected.

.

 Vital signs of the victim should be recorded and noted. We should look for the sign of struggle to overcome the violence which may present in any form such as

Abrasions, nail scratches, bruises, bite marks,  lacerations, incised and stab wounds, etc. Any injuries present should be properly documented, incorporating  sketches or photographs whenever possible,  giving exact location, detailed description: size,  shape,type of injury, age of injury, etc

 

Genital/Local Examination: Following requirement should be arranged for genital examination.

Ø Position:  Proper examination is possible only by making

          the patient adopt the lithotomy position .

Ø Proper illumination:  This can help in  good observation.

Ø Local anaesthesia: Use of local anasthesia may be beneficial when the victim is complaining of severe pain.

Ø Examination proper: Findings differ depending on the  victim who could be a virgin, deflorated woman, or a child. Now we shall discuss those findings.

 

Findings in a Virgin Victim

All findings are described as typical findings of rape and become

corroborative evidence in law and these are as followings.

• On the vulva – redness, bruises, swellings, tears, scratches, bleeding, etc. can be noticed and maybe suggestive of rape.

• With the hymen – Recent rupture is of maximum corroborative value. The site and degree of tears should be noted. Hymen examination kit should be used.

• In the vagina – bruises, tears, bleeding, discharges (venereal origin), foreign particles, etc. Menstrual flow may be there if the victim is in her menstruating period.

Findings in Deflorated Woman Victim

Typical findings described in the virgin victim may not be elicited in a deflorated woman victim. However, presence of the following is important in such cases:

• Semen in the vagina (in fornices or vulva or garments worn).  And that can be confirmed by vaginal smear.

• Evidence of struggle is more important these victims because of the lack of typical genital findings in these patients. Perineal tears can be anticipated in such patients suggested by uncontrolled bleeding or clotted blood.

• Discharges of lesions of sexually transmitted infections such as gonorrhea, syphilis, etc. if present noted.

 

 

Hymen Examination :Hymen examination is an essential step in the examination of a rape victim if the victim is unmarried. It is done with a special kit called ‘hymen examination kit’ that comprises of a set of glass rods of varying sizes with a spherical bulbous expansion at one end.

Collection of Evidence: Rape is an excellent example for Locard’s Principle of Exchange which states that every contact leaves a trace. Physical and biological evidence play a pivotal role in the objective and scientific reconstruction

of the events in question. The evidence should be collected from the victim, from the crime scene and from the suspect employing standard techniques. Each sample should be packed using appropriate packaging materials, labelled, sealed and stored as per specification before transporting it to the laboratories. Documented chain of custody of the evidence should be maintained strictly at every level to ensure the authenticity of the evidence.

1. Stains and foreign materials present on the clothing or body.

2. Fingernail scrapings.

3. Brushing/combing of the person’s hairy region: head, body and pubic.

4. Samples of the person’s hair: head, body and pubic.

5. Urethral, perianal, vulvar swabs, vaginal content aspiration and swab, and cervical swab to be collected under direct visualisation. Ideally it should be collected prior to the examination to avoid contamination.

6. Sample of blood

Detection of semen

The type of physical evidence most frequently associated with

sexual assault cases is semen. The presence of semen is indicative of the occurrence of sexual activity.

Process of Collecting Biological Samples

a. Dried Stains: Application of absorbent swabs moistened in distilled water or normal saline.

b. Wet Stains: Under direct visualisation any liquid secretions in the body cavities can be collected by aspiration or insertion of dry absorbent swabs.

Various screening test are done for the indentification of occult seminal stains like ultraviolet light scanning and chemical tests like Barberios test and fluorescent test.

Other chemical markers can be used as well for seminal content in the stain like alkaline phosphatase,  creatinine phosphokinase, lactate

dehydrogenase isoenzymes, etc.

Confirmatory Tests for detection of semen from stains extract

The seminal stain is processed for extraction, which yields a supernatant and a cell pellet. The cell pellet is used for detection of spermatozoa and for DNA analysis while the supernatant portion is used for detection of noncellular markers in semen and to develop genetic profiling or grouping. Depending on the time elapsed since the crime, spermatozoa may be alive and motile or dead. Identification of one or more spermatozoa is conclusive proof of the presence of semen and affirms sexual

contact.

 

 

Examination of the Accused

The accused of a rape case can be made to present for medicolegal examination. Except some differences, the procedure is almost the same as with examination of rape victim.

Ø Genital Examination: Following things can be noted and should be looked for.

Ø Injuries suggestive of forcible sexual intercourse such as bruises, nail scratch marks, etc. by the victim in resisting the act of rape

Ø Tearing of prepuce, frenulum, etc. due to forcible penetration can be noted.

Ø Swabs from the urethra, shaft and glans are collected in addition to the above-mentioned physical evidence.

Lugol’s iodine test: During sexual intercourse, vaginal epithelial cells,

which are transferred to glans penis are confirmed by this test in the accused individuals. In this test glans penis is mopped with a filter paper and the paper is then exposed to Lugol’s iodine vapor. A brownish discoloration on the paper is suggestive of presence of vaginal epithelium, which is rich in glycogen

content, responsible for color change on the paper.

 

SIGNIFICANCE OF MEDICAL EXAMINATION OF SEXUAL ASSAULT

Medical evidence of rape can be derived from:

• Presence of stains of body fluid and foreign materials in the clothing and body including genitalia of the victim or vice

versa.

• Presence of marks of struggle or violence in the body and clothing inflicted by the accused or vice versa.

• Evidence of injuries in and around genitalia of the victim.

• Presence of semen in the vagina of the victim.

• Evidence of implanted venereal disease on the body of the

victim.

In the legal context, to constitute the offence of rape there need not be full penetration of the vagina by the penis with emission of semen and rupture of hymen. Even the slightest penetration or even touching the vulva without

producing any injury to the genitals including hymen or leaving any evidence of seminal emission will be sufficient to conclude that was a rape case.

As per that view the proof of seminal emission in a victim who is below 16 years of age or injuries in the genitals provides the proof of rape.

Documentation

Documentation should contain following details of rape victim:

 

1. Name and address:

2. Age as stated by:

3. Occupation:

4. Married or not:

5. Number of children if married:

6. Persons accompanying and their relationship:

7. Consent—Obtained from parents in the case of minor girls. Always get signature.

8. Nurse or other female present

9. Marks of identification

10. History as given by the police

11. History as given by parents/relatives

12. Statement of the female with regard to the following:

• Date, time and place of occurrence

• Exact position of the parties

• Did she struggle or cry for help?

• Was she menstruating or not?

• Was she conscious the whole time?

• Did she urinate or not? Pain?

• Did she change her clothes?

13. Date and time of lodging a complaint, explain delay

14. Date and time of physical examination

15. Mental disposition. Excited or calm

16. Gait. Does she walk as if in pain?

17. Clothes—look for blood, semen, hair, tears, loss of buttons, mud, grass, etc. Describe location and extent of each.

18. Physical development—height, weight, build.

19. Marks of general violence—look for abrasions or contusions of face, back of the shoulder, arms, and thighs.

20. Breasts—look for contusion, abrasion, and bitten nipples.

21. Pubis, perineum, thighs—look for stains, matting of hair, scratches.

22. Vulva—look for bruises, abrasions

23. Hymen—present or replaced by carunculae, if present—type, position of natural opening, whether torn/intact, if torn—

position, extent and age of tear.

24. Fourchette—intact/torn.

25. Vagina—look for bruises, tear, nature of discharge

26. Veneral disease—gonorrhea/syphilis—get specialist’s opinion if it is necessary and possible.

27. Vaginal smear—for spermatozoa, blood.

28. Preserve following material for chemical examination

29. Clothes are dried to prevent decomposition of stains. Put in a cardboard box, seal, and label.

30. Take vaginal fluid with a swab

.

 

 

 

 

We do not own any of the contents in this blog. We are not hosting any copyrighted content, all the links provided in this blog are just randoms links already available somewhere in the internet. All the contents in this blog are only for educational purposes. If you think your right is infringed in any way, please let us know at js2269335@gmail.com. We will remove the link as soon as possible.

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